Modulation of Angiogenesis during Adipose Tissue Development in Murine Models of Obesity

• DOI: 10.1210/en.2005-0532
• Publication Date: 2005-07-15T00:14:08Z
• Authors: Gabor Voros; Erik Maquoi; Diego Demeulemeester; Natalie Clerx; Désiré Collen; H. Roger Lijnen
• Keywords: Thrombospondin 1; Angiopoietin; Adipose tissue macrophages

Development of vasculature and mRNA expression 17 pro- or antiangiogenic factors were studied during adipose tissue development in nutritionally induced genetically determined murine obesity models. Subcutaneous (SC) gonadal (GON) fat pads harvested from male C57Bl/6 mice kept on standard chow [standard diet (SFD)] high-fat for 0-15 wk ob/ob SFD. Ob/ob had significantly larger SC GON pads, accompanied by higher blood content, increased total vessel volume, number proliferating cells. protein levels angiopoietin (Ang)-1 down-regulated, whereas those thrombospondin-1 up-regulated developing both Ang-1 correlated negatively with weight the early phase as well obesity. Placental growth factor Ang-2 mice, thrombospondin-2 was their pads. vascular endothelial (VEGF)-A isoforms VEGF-B, VEGF-C, VEGF receptor-1, -2, -3, neuropilin-1 not markedly modulated This modulation angiogenic supports important functional role