Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome

• DOI: 10.1210/en.2007-0175
• Publication Date: 2007-07-20T00:44:26Z
• Authors: Kiymet Bozaoglu; Kristy Bolton; Janine McMillan; Paul Zimmet; Jeremy Jowett; Greg Collier; Ken Walder; David Segal
• Keywords: Chemerin

Soluble protein hormones are key regulators of a number metabolic processes, including food intake and insulin sensitivity. We have used signal sequence trap to identify genes that encode secreted or membrane-bound proteins in Psammomys obesus, an animal model obesity type 2 diabetes (T2D). Using this trap, we identified the chemokine chemerin as being novel adipokine. Gene expression its receptor, chemokine-like receptor 1 (CMKLR1), was significantly higher adipose tissue obese diabetic P. obesus compared with lean, normoglycemic obesus. Fractionation confirmed predominantly expressed adipocytes, whereas CMKLR1 both adipocytes stromal-vascular cells tissue. In 3T3-L1 markedly induced during differentiation, down-regulated differentiation. Serum levels were measured by ELISA human plasma samples from 114 subjects T2D 142 normal glucose tolerant controls. Plasma not different between However, subjects, associated body mass index, circulating triglycerides, blood pressure. Here report, for first time, is adipokine, several aspects syndrome.