Impaired Central Insulin Response in Aged Wistar Rats: Role of Adiposity

• DOI: 10.1210/en.2007-0543
• Publication Date: 2007-08-03T00:58:55Z
• Authors: Miriam García-Sa...; Teresa Fernández...; Alain J. De Solís; Antonio Andrés; Carmen Arribas; José M. Carrascosa; Manuel Ros
• Keywords: Male; 0301 basic medicine; 2. Zero hunger; Aging; Biología; Diabetes; Body Weight; Hypothalamus; Péptidos; Rats; Eating; 03 medical and health sciences; Animals; Insulin; Insulin Resistance; Rats, Wistar; Adiposity; Injections, Intraventricular; Signal Transduction

Insulin, like leptin, is considered as a lipostatic signal acting at central level. Aging and age-associated adiposity have been related to the development of leptin resistance in Wistar rats. In present article, hypothalamic insulin response during aging has studied Thus, effects intracerebroventricular infusion week on food intake body weight well transduction after acute administration 3-, 8-, 24-month-old To explore possible role adiposity, these experiments were also performed 8- rats 3 months restriction reduce visceral index values below those young animals. Intracerebroventricular was more efficient reducing 3-month-old than Hypothalamic insulin-stimulated receptor, GSK3, AKT, p70S6K phosphorylation decreased with aging. Insulin receptor IRS-2 phosphoserine increased Food improved both responsiveness signaling. These data suggest that develop This can be explained by alterations pathway. The fact improves points key player resistance.