Differential Interactions between Th1/Th2, Th1/Th3, and Th2/Th3 Cytokines in the Regulation of Thyroperoxidase and Dual Oxidase Expression, and of Thyroglobulin Secretion in Thyrocytes in Vitro

• DOI: 10.1210/en.2007-1316
• Publication Date: 2008-01-11T01:35:08Z
• Authors: Sylvie Poncin; Benoit Lengelé; Ides M. Colin; Anne-Catherine Ge...
• Keywords: Thyroglobulin; Thyroid peroxidase; Proinflammatory cytokine; Autoimmune thyroiditis

Hypothyroidism, together with glandular atrophy, is the usual outcome of destructive autoimmune thyroiditis. The impairment in thyroid function results either from cell destruction or Th1 cytokine-induced alteration hormonogenesis. Here, we investigated impact local immune context on function. We used two rat lines (PCCL3 and FRTL-5) human thyrocytes incubated IL-1α/interferon (IFN) γ IL-4, a Th2 cytokine, TGF-β, IL-10, Th3 cytokines. first observed that IL-4 totally blocked γ-induced dual oxidase thyroperoxidase expression, thyroglobulin secretion. By contrast, TGF-β IL-10 had no such effect. They rather repressed thyrocyte as do In addition, IL-10-induced repression function, but not induced by TGF-β. conclusion, cytokine- inhibitory actions can be overturned These data provide new clues about influence