Maternal Fructose Intake during Pregnancy and Lactation Alters Placental Growth and Leads to Sex-Specific Changes in Fetal and Neonatal Endocrine Function

• DOI: 10.1210/en.2010-1093
• Publication Date: 2011-02-09T03:05:55Z
• Authors: M. H. Vickers; Z. E. Clayton; C. Yap; D. M. Sloboda
• Keywords: Hyperinsulinemia

Abstract The effects of maternal fructose intake on offspring health remain largely unknown, despite the marked increase in consumption sweetened beverages that has paralleled obesity epidemic. present study investigated impact placental, fetal, and neonatal development. Female Wistar rats were time-mated allocated to receive either water [control (CONT)] or solution designed provide 20% caloric from (FR). FR was administered d 1 pregnancy until postnatal day (P) 10. All dams had ad libitum access standard laboratory chow water. Dams killed at embryonic (E) 21 P10. demonstrated increased total hyperinsulinemia E21 as well plasma levels did not alter blood glucose, β-hydroxybutyrate (BHB), electrolyte time point. Fetal weights unchanged, although placental reduced female but male fetuses. Plasma leptin, fructose, glucose BHB decreased insulin different between CONT groups. Male neonates higher hypoinsulinemic euglycemic P10 compared with CONT. Blood females leptin Stomach content all P10, no differences stomach observed. This reports for first resulted sex-specific changes development, whereby appear more vulnerable metabolic compromise during life. Independent follow-up studies are essential investigate long-term consequences health.