Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice

• DOI: 10.1210/en.2010-1312
• Publication Date: 2011-03-23T02:33:08Z
• Authors: Shiho Fujisaka; Isao Usui; Yukiko Kanatani; Masashi Ikutani; Ichiro Takasaki; Koichi Tsuneyama; Yoshiaki Tabuchi; Agussalim Bukhari; Yu Yamazaki; Hikari Suzuki; Satoko Senda; Aminuddin Aminuddin; Yoshinori Nagai; Kiyoshi Takatsu; Masashi Kobayashi; Kazuyuki Tobe
• Keywords: Telmisartan; Adipose tissue macrophages; Macrophage polarization; Hyperinsulinemia; CD163; Proinflammatory cytokine

Diet-induced obesity is reported to induce a phenotypic switch in adipose tissue macrophages from an antiinflammatory M2 state proinflammatory M1 state. Telmisartan, angiotensin II type 1 receptor blocker and peroxisome proliferator-activated receptor-γ agonist, reportedly has more beneficial effects on insulin sensitivity than other blockers. In this study, we studied the of telmisartan macrophage phenotype high-fat-fed mice. Telmisartan was administered for 5 wk C57BL/6 Insulin sensitivity, infiltration, gene expressions markers visceral tissues were then examined. An insulin- or glucose-tolerance test showed that treatment improved resistance, decreasing body weight gain, fat weight, adipocyte size without affecting amount energy intake. reduced mRNA expression CD11c TNF-α, markers, significantly increased such as CD163, CD209, galactose N-acetyl-galactosamine specific lectin (Mgl2), quantitative RT-PCR analysis. A flow cytometry analysis decreased number tissues. conclusion, improves modulates polarization