Short-Term Pharmacological Suppression of the Hyperprolactinemia of Infertile hCG-Overproducing Female Mice Persistently Restores Their Fertility

• DOI: 10.1210/en.2012-1393
• Publication Date: 2012-11-02T07:08:39Z
• Authors: Laura D. Ratner; Betina Gonzalez; Petteri Ahtiainen; Noelia P. Di Giorgio; Matti Poutanen; Ricardo S. Calandra; Ilpo T. Huhtaniemi; Susana B. Rulli
• Keywords: Ovulation; Cabergoline; Time Factors; Cabergolina; Prolactina; Mice, Transgenic; ta3111; Chorionic Gonadotropin; Mice; 03 medical and health sciences; 0302 clinical medicine; https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/3.1; Animals; Humans; https://purl.org/becyt/ford/3; Ergolines; https://purl.org/becyt/ford/1; Bromocriptine; Gonadotrofina Corionica Humana; 3. Good health; Hyperprolactinemia; Disease Models, Animal; Fertilidad; Fertility; Phenotype; Gene Expression Regulation; Reproduction-Development; Infertility; Female

Female infertility is often associated with deregulation of hormonal networks, and hyperprolactinemia one the most common endocrine disorders hypothalamic-pituitary axis affecting reproductive functions. We have shown previously that transgenic female mice overexpressing human chorionic gonadotropin β-subunit (hCGβ+ mice), producing elevated levels bioactive LH/hCG, exhibit increased production testosterone progesterone, are overweight infertile, develop pituitary lactotrope adenomas in adult age. In present study, we analyzed influence hCGβ+ females on their phenotype by treating them dopamine agonists, bromocriptine cabergoline. Long-term treatment was effective control obesity, growth, disturbances hormone profile, demonstrating main cause phenotype. Interestingly, short-term (1 wk) cabergoline applied 5-wk-old corrected hyperprolactinemia, hyperandrogenism, hyperprogesteronemia, prevented overgrowth, normalized gonadal function, recovered fertility after hormone-induced natural ovulation. The same short term 3-month-old failed to recover function. Hence, demonstrated at a critical early stage progression effectively hyperprolactinemia-associated dysfunction hCG-overproducing females.