Gestational Hypothyroidism Improves the Ability of the Female Offspring to Clear Streptococcus pneumoniae Infection and to Recover From Pneumococcal Pneumonia

• DOI: 10.1210/en.2015-1957
• Publication Date: 2016-04-01T17:02:04Z
• Authors: Pamela A. Nieto; Hernán F. Peñaloza; Francisco J. Sala...; Raquel M. Castell...; Maria Cecilia Opazo; Luis Venegas; Oslando Padilla; Alexis M. Kalergis; Claudia A. Riedel; Susan M. Bueno
• Keywords: Pneumococcal pneumonia

Maternal thyroid hormones are essential for proper fetal development. A deficit of these during gestation has enduring consequences in the central nervous system offspring, including detrimental learning and impaired memory. Few studies have shown that hormone deficiency a transient effect number T B cells offspring gestated under hypothyroidism; however, there no showing whether maternal hypothyroidism impacts response to infections. In this study, we evaluated adult mice hypothyroid mothers an altered pneumococcal pneumonia. We observed female increased survival rate less bacterial dissemination blood brain after intranasal challenge with Streptococcus pneumoniae. Further, had higher amounts inflammatory lungs reduced production cytokines characteristic sepsis spleen, blood, at 48 hours infection. Interestingly, basally vascular permeability lungs. These observations suggest gestational alters immune physiology increasing resistance respiratory