The Response of Prostate Smooth Muscle Cells to Testosterone Is Determined by the Subcellular Distribution of the Androgen Receptor

• DOI: 10.1210/en.2017-00718
• Publication Date: 2017-11-29T14:36:29Z
• Authors: Nahuel Peinetti; María Victoria Sc...; Mariana Micaela C...; Carolina Leimgruber; Juan Pablo Nicola; Alicia Ines Torres; Amado Alfredo Qui...; Cristina Alicia M...
• Keywords: Proinflammatory cytokine

Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of homeostasis, alterations which are a central aspect development pathological conditions. Testosterone can act through classic androgen receptor (AR) cytoplasm, eliciting genomic signaling, or different types receptors located at plasma membrane nongenomic signaling. We aimed to find evidence testosterone-signaling mechanisms pSMCs and their participation cell proliferation, differentiation, modulation response lipopolysaccharide. demonstrated that respond testosterone by rapid activation ERK1/2 Akt. Furthermore, pool ARs localized surface responsible testosterone-induced increase proliferation. Through stimulation, favors phenotype, indicated an markers. also showed anti-inflammatory effects testosterone, capable attenuating lipopolysaccharide-induced proinflammatory actions, promoted only inside cell. postulate might perform prohomeostatic intracellular-initiated modulating proliferation inflammation, whereas some pathological, hyperproliferative actions would be induced membrane-initiated pSMCs.