In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis.

• DOI: 10.1210/endo.131.4.1396316
• Publication Date: 2014-01-08T16:05:18Z
• Authors: R A Memon; K R Feingold; A H Moser; W Doerrler; C Grunfeld
• Keywords: Ketogenesis; Alpha (finance)

The host response to infection and cancer produces disturbances in fatty acid (FA) oxidation ketogenesis. Interferons (IFNs) stimulate lipolysis cultured adipocytes. Since FA mobilization is a major stimulus for ketogenesis, we studied the effect of IFN alpha gamma on ketogenesis intact mice. Both IFNs acutely stimulated lipolysis; however, their effects differed. INF increased serum hepatic ketone body levels parallel its FFA, whereas exerted biphasic At low doses, levels, at higher this ketogenic was abolished. To determine mechanism response, malonyl-coenzyme-A (malonyl-CoA), first committed intermediate synthesis an inhibitor had no malonyl-CoA; doses significantly malonyl-CoA which could counterbalance FFA. In contrast, little malonyl-CoA, hence, not opposed. By using phenylisopropyladenosine block IFN-induced lipolysis, found that absence flux, did exert effect. However, when alpha-induced blocked, raise were antiketogenic. These data suggest both by stimulating but counteracted synthesis.