Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

• DOI: 10.1210/endo.133.6.8243312
• Publication Date: 2014-01-08T16:06:00Z
• Authors: T B Usdin; E Mezey; D C Button; M J Brownstein; T I Bonner
• Keywords: Gastric inhibitory polypeptide; Secretin family; Secretin; Enteroendocrine cell

Gastric inhibitory polypeptide (GIP), or glucose-dependent insulinotropic peptide, is released from endocrine cells in the small intestine after meals. It involved several facets of anabolic response and thought to be particularly important stimulating insulin secretion. We have cloned, functionally expressed, mapped distribution receptor for GIP. a member secretin-vasoactive intestinal family G-protein-coupled receptors. When expressed tissue culture cells, it stimulates cAMP production (EC50 0.3 nM) also increases intracellular calcium accumulation. GIP mRNA present pancreas as well gut, adipose tissue, heart, pituitary, inner layers adrenal cortex, whereas not found kidney, spleen, liver. brain regions, including cerebral hippocampus, olfactory bulb. These results suggest that may previously undescribed actions. localization cortex suggests effects on glucocorticoid metabolism. Neither nor its been described central nervous system, known peptide ligand cannot detected by situ hybridization polymerase chain reaction. This novel brain.