Adiponectin in Human Cord Blood: Relation to Fetal Birth Weight and Gender

• DOI: 10.1210/jc.2003-031174
• Publication Date: 2003-12-11T22:23:51Z
• Authors: Eyal Sivan; Shali Mazaki-Tovi; Clara Pariente; Yael Efraty; Eyal Schiff; Rina Hemi; Hannah Kanety
• Keywords: Cord blood

Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. The aim of this study was to examine whether adiponectin present in human fetal blood, define its association birth weight, evaluate dynamic changes levels occur during the early neonatal period. Cord blood were extremely high (71.0 +/- 21.0 microg/ml; n = 51) compared serum children adults positively correlated weights (r 0.4; P < 0.01). No significant differences found between female male neonates. In addition, there no correlation cord maternal body mass index, leptin, or insulin levels. significantly higher at (61.1 19.0 vs. 17.6 4.9 0.001; 17), There 4 d postpartum 63.8 22.0 17). These findings indicate that derived from not placental tissues. newborns may be due lack negative feedback on production resulting adipocyte hypertrophy, low percentage fat, a different distribution fat depots newborns.