Adiponectin, Inflammation, and the Expression of the Metabolic Syndrome in Obese Individuals: The Impact of Rapid Weight Loss through Caloric Restriction

• DOI: 10.1210/jc.2003-031826
• Publication Date: 2004-06-04T21:48:10Z
• Authors: Antonios M. Xydakis; Christopher C. Case; Peter H. Jones; Ron C. Hoogeveen; Mine-Yine Liu; E. O’Brian Smith; Kathleen W. Nelson; Christie M. Balla...
• Keywords: Blood Glucose; Inflammation; Leptin; Male; Metabolic Syndrome; 2. Zero hunger; Diet, Reducing; Tumor Necrosis Factor-alpha; Proteins; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Weight Loss; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Female; Adiponectin; Obesity; Energy Intake; Triglycerides

Severe obesity increases the prevalence of metabolic syndrome, and moderate acute weight loss with a very low-calorie diet in obese subjects syndrome leads to significant benefits. Adiponectin has been implicated both pathogenesis obesity-related insulin resistance increased inflammation. We analyzed relationship adipocyte-derived hormone adiponectin indices inflammation, adiposity, (MS+, n = 40) without (MS−, examined effects rapid loss. MS+ had significantly lower (7.6 ± 0.6 vs. 10.4 μg/ml; P 0.003) higher TNF-α (3.3 0.2 2.8 0.3 pg/ml; 0.004) levels compared MS− matched for age body mass index. Plasma were inversely related number factors stepwise manner. After 4–6 wk loss, there was marked improvement glucose, insulin, leptin, triglycerides, whereas concentrations did not change. Thus, plasma or reductions are required improvements glucose/insulin lipid metabolism