Impaired Insulin Secretion in the Turner Metabolic Syndrome

• DOI: 10.1210/jc.2004-0122
• Publication Date: 2004-07-07T17:44:07Z
• Authors: Vladimir K. Bakalov; Margaret M. Cooley; Michael J. Quon; Mei Lin Luo; Jack A. Yanovski; Lawrence M. Nelson; Gail Sullivan; Carolyn A. Bondy
• Keywords: Haploinsufficiency; Monosomy; Glucose tolerance test

An increased prevalence of impaired glucose homeostasis (IGH) and diabetes mellitus is reported in monosomy X, or Turner syndrome (TS). To determine whether IGH an intrinsic feature this syndrome, independent obesity hypogonadism, we compared results a standard oral challenge age- body mass index-matched women with TS karyotypically normal premature ovarian failure (POF). Fasting levels were both groups, but values after higher [2-h glucose, 135 +/- 36 mg/dl (7.5 2.0 mmol/liter) 97 18 (5.4 1.0 POF; P < 0.0001]. Glucose-stimulated insulin secretion was lower TS; e.g. the initial response (DeltaI/DeltaG(30)) decreased by 60% POF (P 0.0001). We also responses to iv tolerance test found that area under curve 50% = 0.003). Insulin sensitivity measured quantitative check index control groups. Thus, not secondary hypogonadism TS, it distinct entity characterized secretion, suggesting haploinsufficiency for X-chromosome gene(s) impairs beta-cell function predisposes TS.