Efficacy of Adjuvant Radiotherapy of the Tumor Bed on Local Recurrence of Adrenocortical Carcinoma

• DOI: 10.1210/jc.2006-1007
• Publication Date: 2006-08-09T03:28:27Z
• Authors: Martin Fassnacht; Stefanie Hahner; Buelent Polat; Ann-Cathrin Koschker; Werner Kenn; Michael Flentje; Bruno Allolio
• Keywords: Mitotane

Local tumor recurrence is common in adrenocortical carcinoma (ACC) and the most frequent cause for reoperation. Although radiotherapy often considered ineffective treatment of ACC, limited number available studies does not support this statement.The objective study was investigation adjuvant bed irradiation ACC.We performed a retrospective analysis.The German ACC Registry (n = 285) screened patients who had received an setting (no macroscopic evidence residual disease after surgery). Fourteen without distant metastases (World Health Organization stage I, one patient; II, seven; III, three; IV, three) were matched with 14 resection status, mitotane treatment, stage, size. Median follow-up still alive 15) 37 months.Survival local disease-free survival main outcome measure.Local observed two group 11 control patients. The probability to be free 5 yr surgery differed significantly [79% (95% confidence interval, 53-100) vs. 12% (0-30); P < 0.01]. However, overall different between groups. Acute adverse events related mostly mild. One patient developed partial Budd-Chiari syndrome.These data from largest series treated suggest that effective reducing high rate ACC. A randomized trial high-risk needed further evaluate efficacy as option