Characterizing Discrete Subsets of Polycystic Ovary Syndrome as Defined by the Rotterdam Criteria: The Impact of Weight on Phenotype and Metabolic Features

• DOI: 10.1210/jc.2006-1327
• Publication Date: 2006-09-26T22:34:12Z
• Authors: C. K. Welt; J. A. Gudmundsson; G. Arason; J. Adams; H. Palsdottir; G. Gudlaugsdottir; G. Ingadottir; W. F. Crowley
• Keywords: Hyperandrogenism; Free androgen index

The Rotterdam criteria for polycystic ovary syndrome (PCOS) defines discrete subgroups whose phenotypes are not yet clear.The phenotypic characteristics of women in the PCOS defined by were compared.The study was observational.Subjects studied an outpatient setting Boston and Reykjavik.Four subjects with 1) irregular menses (IM), hyperandrogenism (HA), morphology (PCOM, n = 298); 2) IM/HA (n 7); 3) HA/PCOM 77); 4) IM/PCOM 36) a group controls 64), aged 18-45 yr, examined.Subjects underwent physical exam; fasting blood samples androgens, gonadotropins, metabolic parameters; transvaginal ultrasound.The phenotype compared between groups.Ninety-seven percent had PCOM. Therefore, groups without PCOM combined. Ferriman-Gallwey score androgen levels highest hyperandrogenic (IM/HA HA/PCOM), whereas ovarian volume higher all controls, as expected based on definitions subgroups. Body mass index insulin subgroup.Subjects most severely affected basis levels, volumes, levels. Their body partially accounts increased suggesting that weight gain exacerbates symptoms PCOS.