Changes in Body Composition in Women over Six Years at Midlife: Ovarian and Chronological Aging

• DOI: 10.1210/jc.2006-1393
• Publication Date: 2006-12-28T01:13:35Z
• Authors: MaryFran Sowers; Huiyong Zheng; Kristin Tomey; Carrie Karvonen-G...; Mary Jannausch; Xizhao Li; Matheos Yosef; James Symons
• Keywords: Bioelectrical Impedance Analysis; Circumference

Context: Understanding the menopause association with body weight is important because excess increases risk for stroke, incident cardiovascular disease, mortality, and all-cause mortality among middle-aged. Objective: The objective of this study was to examine chronological age ovarian consider how these could influence size composition in midlife women. Design Setting: Study Women’s Health Across Nation a longitudinal, community-based study. This report uses data from Michigan site. Participants: Participants were 543 premenopausal or early perimenopausal African-American Caucasian women aged 42–52 yr at baseline examination. Main Outcome Measures: Waist circumference, fat mass skeletal muscle mass, bioelectrical impedance, assessed seven annual serial measures. Annual FSH values assayed by ELISA. final menstrual period defined retrospectively after 12 months amenorrhea. Results: There an absolute cumulative 6-yr increase 3.4 kg decrease approximately 0.23 kg. 5.7 cm waist circumference. logFSH change positively correlated log(fat mass) change. circumference increased over time period, but 1 rate slowed. Fat continued no rate. Conclusions: Both (chronological aging) aging contributed substantial changes (fat These have ramifications establishing metabolic environment that can be healthy unhealthy.