Serum Adiponectin and Bone Mineral Density in Women

• DOI: 10.1210/jc.2006-2097
• Publication Date: 2007-02-02T22:44:35Z
• Authors: J. B. Richards; A. M. Valdes; K. Burling; U. C. Perks; T. D. Spector
• Keywords: Deoxypyridinoline

Bone mineral density (BMD) is positively associated with body weight. This association persists even at non-load bearing sites, suggesting that a nonmechanical factor such as an adipocyte-derived hormone may modulate BMD.The objective of the study was to evaluate relationship between adiponectin, hormone, and BMD.A total 1735 nondiabetic women were recruited from large, population-based cohort (mean age, 50.0 yr). We employed linear regression methods estimate adiponectin BMD.Percentage change in BMD (as measured hip, spine, femoral neck, forearm) markers bone turnover doubling fasting serum levels measured.Employing age-adjusted analysis, each mean 2.7% decrease [total -3.2% (95% confidence interval, -4.1, -2.3); -3.1% (-4.0, -2.1); forearm, -2.0 (-2.6, -1.4); -2.6 (-3.5, -1.7)]. After adjustment for potential confounding factors, including BMI, leptin, central fat mass, replacement therapy, smoking, exercise, this persisted, although decreased magnitude. When stratified by menopausal status, strengthened postmenopausal but disappeared premenopausal women. Serum osteocalcin not urine deoxypyridinoline.After measures fat, increasing BMD, sites. These data suggest play role metabolism through mechanisms effect be mediated status.