Serum Retinol-Binding Protein 4 Concentration and Its Ratio to Serum Retinol Are Associated with Obesity and Metabolic Syndrome Components in Children

• DOI: 10.1210/jc.2007-0468
• Publication Date: 2007-08-29T02:34:17Z
• Authors: Isabelle Aeberli; Ralf Biebinger; Roger Lehmann; Dagmar l’Allemand; Giatgen A. Spinas; Michael B. Zimmer...
• Keywords: Retinol binding protein; Subclinical infection

Although retinol-binding protein (RBP)-4 concentrations are elevated in animal models of obesity and insulin resistance (IR), the link between RBP4 IR humans is less clear. There few published data on levels overweight children, most previous studies did not control for vitamin A (VA) status and/or subclinical inflammation.The objective study was to measure serum RBP4, retinol (SR), RBP4-to-SR molar ratio, dietary VA intakes normal-weight children investigate relationship these variables IR, inflammation, metabolic syndrome this age group.This a cross-sectional study.The conducted Northern Switzerland.Patients included 6- 14-yr-old normal-weight, overweight, obese (n = 79).Body mass index, body fat percentage, waist-to-hip intakes, SR were determined. assessed using fasting quantitative sensitivity check components indices inflammation measured.Only 3% had low status. Independent age, C-reactive protein, ratio significant predictors SR, RBP4/SR. adiposity, RBP4/SR significantly correlated with triglycerides, insulin. The more strongly than RBP4.Independent obesity, central prepubertal early pubertal children.