Calorie Restriction Modulates Inactivity-Induced Changes in the Inflammatory Markers C-Reactive Protein and Pentraxin-3

• DOI: 10.1210/jc.2007-1684
• Publication Date: 2008-05-21T03:24:30Z
• Authors: Alessandra Bosutti; Grazia Malaponte; Michela Zanetti; Pietro Castellino; Martina Heer; Gianfranco Guarnieri; Gianni Biolo
• Keywords: Adult; Inflammation; Male; C reactive protein; Interleukin-6; bed rest; calorie restriction; Motor Activity; Interleukin-10; 3. Good health; Serum Amyloid P-Component; 03 medical and health sciences; bed rest; inactivity; calorie restriction; pentraxin-3; C reactive protein; C-Reactive Protein; 0302 clinical medicine; inactivity; pentraxin-3; Humans; RNA, Messenger; Caloric Restriction

Abstract Context: Energy balance and physical activity potentially influence systemic inflammation. Objective: Our objective was to test the hypothesis that moderate energy restriction may prevent activation of inactivity-induced inflammatory response. Design: Participants were studied four times at end 14-d periods experimental bed rest or controlled ambulation, after receiving eucaloric hypocaloric diets. Setting: The study conducted clinical research center German Space Agency. Subjects: Nine healthy young volunteers participated. Interventions: intake calibrated decreased by about 20% in conditions. Main Outcome Measures: Changes body fat dual-energy x-ray absorptiometry as well plasma markers cytokine mRNA levels blood cells measured. Results: Fat mass did not change significantly conditions (−1.0 ± 0.3 −1.0 kg ambulatory rest, respectively). Bed increased C-reactive protein (CRP) (+143 53%) both ratios between IL-6 IL-10 (4±1 times) white cell mRNAs (5 1 times). prevented bed-rest-mediated increases CRP ratio. (P = 0.03) long pentraxin-3 (PTX3) concentration, without significant activity-by-diet interaction. In all (n 36), PTX3 inversely correlated (r −0.61; P < 0.001). mass, leptin, directly with PTX3. 0.52; 0.01). Conclusions: Calorie prevents response induced 14 d rest. We suggest an inverse regulation changes balance.