Plasma Osteopontin Increases After Bariatric Surgery and Correlates with Markers of Bone Turnover But Not with Insulin Resistance

• DOI: 10.1210/jc.2007-2383
• Publication Date: 2008-03-12T03:33:44Z
• Authors: Michaela Riedl; Greisa Vila; Christina Maier; Ammon Handisurya; Soheila Shakeri-M...; Gerhard Prager; Oswald Wagner; Alexandra Kautzky...; Bernhard Ludvik; Martin Clodi; Anton Luger
• Keywords: Homeostatic model assessment; N-terminal telopeptide; Osteopontin; Bone remodeling

Osteopontin (OPN) is a multifunctional protein involved in bone metabolism, cardiovascular disease, diabetes, and obesity. OPN levels are elevated the plasma adipose tissue of obese subjects, decreased with diet-induced weight loss.We investigated effect bariatric surgery on concentrations morbidly patients.The study was performed at university hospital.We 40 patients aged 43.1 +/- 1.8 yr, scheduled to undergo surgery. Roux-en-Y gastric bypass (RYGB) 30 subjects (27 females, three males), laparoscopic adjustable banding (LAGB) 10 (eight two males).All were studied before 1 yr (10.3-14.8 months) after intervention.OPN, leptin, C-reactive protein, insulin, homeostatic model assessment insulin resistance index, calcium, 25-hydroxyvitamin D, C telopeptide, osteocalcin determined.Both procedures significantly reduced body weight, mass Plasma increased from 31.4 3.8 52.8 3.7 ng/ml RYGB (P < 0.001) 29.8 6.9 46.4 10.6 LAGB = 0.042). Preoperative correlated age, postoperative OPN. Postoperative telopeptide osteocalcin.One year LAGB, biomarkers turnover. Unlike other proinflammatory cytokines, does not normalize but increases further