Materno-Fetal Cardiovascular Complications in Turner Syndrome after Oocyte Donation: Insufficient Prepregnancy Screening and Pregnancy Follow-Up Are Associated with Poor Outcome

• DOI: 10.1210/jc.2010-0925
• Publication Date: 2010-12-09T02:16:14Z
• Authors: Nicolas Chevalier; Hélène Letur; Dominique Lelannou; Jeanine Ohl; Dominique Cornet; Cécile Chalas-Boi...; René Frydman; Sophie Catteau-Jo...; Thérèse Greck-Cha...; Aline Papaxanthos...; Marie-Christine D...; Marie-Laure Couet; Isabelle Cédrin-D...; Jean-Luc Pouly; Patrick Fénichel
• Keywords: Gestational hypertension; Live birth

Recombinant human GH treatment and oocyte donation (OD) have improved the quality of life in women with Turner syndrome (TS). However, expectancy is reduced, mainly due to cardiovascular complications. Pregnancy may itself increase that risk be associated hazardous materno-fetal outcome.The objective this study was evaluate outcome ongoing pregnancies beyond 20 wk gestation obtained by OD TS.This a multicenter retrospective including all assisted reproductive technology centers affiliated French Study Group for Oocyte Donation.Among 93 patients, only 37.6% were prescreened echocardiography or thoracic magnetic resonance imaging. Maternal dominated 37.8% pregnancy-associated hypertensive disorders preeclampsia 54.8% severe eclampsia four patients. Prematurity occurred 38.3% correlated disorder (P = 0.01). The frequency utero growth retardation 27.5%. One fetal demise linked eclampsia. Two patients died from aortic rupture after cesarean section context root dilatation. Only 40% an absolutely normal outcome.OD TS who not been managed following recent specific recommendations at high maternal death dissection its complications (fetal distress retardation). These include previous echocardiography, imaging, overnight blood pressure monitoring tight follow-up during pregnancy. Until future assessment these recommendations, must still considered as very high-risk pregnancies.