Adiponectin Is Associated with Favorable Lipoprotein Profile, Independent of BMI and Insulin Resistance, in Adolescents

• DOI: 10.1210/jc.2010-2364
• Publication Date: 2011-03-02T21:42:39Z
• Authors: Sheela N. Magge; Nicolas Stettler; Dorit Koren; Lorraine E. Levit...; Paul R. Gallagher; Emile R. Mohler; Daniel J. Rader
• Keywords: Lipoprotein particle; High-density lipoprotein

Children with obesity and insulin resistance (IR) have decreased adiponectin increased cardiovascular risk. Adiponectin has antiatherogenic effects, but its mechanism is unclear.Our objectives were 1) to compare lipoprotein subclass particles among obese lean adolescents delineate their relationships IR 2) measure between lipoproteins dependence on body mass index (BMI) and/or IR. DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES: This was a cross-sectional study of 57 38 pubertal adolescents, measuring (nuclear magnetic resonance spectroscopy), lipids, adiponectin, homeostasis model assessment (HOMA-IR).Obese had higher low-density (LDL) cholesterol (P = 0.018), small LDL (LDL-P) < 0.0005), smaller LDL-P size high-density particle (HDL-P) lower HDL (HDL-C) HDL-P 0.009) compared lean. HOMA-IR in than 0.0005) positively associated triglycerides, large very LDL-P, negatively obese. size, HDL-C Using linear regression adjusting for demographics, Tanner stage, BMI, all 0.028), 0.042) 0.004).Obese levels lean, more atherogenic profile, inversely even after the first such report children, suggests relationship independent BMI