Circulating miRNA Profiles in Patients with Metabolic Syndrome

• DOI: 10.1210/jc.2012-1996
• Publication Date: 2012-10-03T01:40:37Z
• Authors: Dwi Setyowati Kar...; Subramaniam Tavin...; Arunmozhiarasi Ar...; Sugunavathi Sepra...; Sharon Li Ting Pek; Michael T. K. Wong; Su Chi Lim; Chee Fang Sum; Kandiah Jeyaseelan
• Keywords: Dyslipidemia; Pathogenesis; Fold change

Coordinated interplay of dysregulated microRNAs in isolated metabolic disorder is implicated the pathogenesis syndrome.The objective study was to characterize microRNA expression blood and exosomes individuals with syndrome compare them those manifesting one vascular risk factors (type 2 diabetes, hypercholesterolemia, or hypertension). RESEARCH DESIGN/SETTING/PARTICIPANTS: A total 265 participants were recruited a health screening characterized into distinct groups as follows: 1) healthy controls (n = 46); 2) 50); 3) type diabetes 4) hypercholesterolemia 89); 5) hypertension 30). Total RNA subjected profiling, panel significantly validated using quantitative PCR.Analysis profiling data unique pools miRNAs that could categorize different syndrome.We have identified miR-197, miR-23a, miR-509-5p potential contributors dyslipidemia (correlation body mass index; P 0.029, 0.021, 0.042, respectively) miR-130a miR-195 pressure; 0.019 0.045, respectively). plausible association miR-27a miR-320a patients has also been found because these remained both cases fasting glucose; 0.010 0.016, respectively).Significant dysregulation seven candidate be associated risks involved manifestation syndrome.