Thyroid Nodules Treated with Percutaneous Radiofrequency Thermal Ablation: A Comparative Study
Adult
Aged, 80 and over
Male
Methimazole
Matched-Pair Analysis
Biopsy, Fine-Needle
Adult; Aged; Aged, 80 and over; Antithyroid Agents; Biopsy, Fine-Needle; Combined Modality Therapy; Female; Humans; Male; Matched-Pair Analysis; Methimazole; Middle Aged; Thyroid Nodule; Thyrotoxicosis; Treatment Outcome; Tumor Burden; Ultrasonography; Catheter Ablation
Middle Aged
Combined Modality Therapy
Tumor Burden
3. Good health
03 medical and health sciences
Thyrotoxicosis
Treatment Outcome
0302 clinical medicine
Antithyroid Agents
Catheter Ablation
Humans
Female
Thyroid Nodule
Aged
Ultrasonography
DOI:
10.1210/jc.2012-2251
Publication Date:
2012-09-30T07:07:30Z
AUTHORS (13)
ABSTRACT
Percutaneous radiofrequency thermal ablation (RTA) was reported as an effective tool for the management of thyroid nodules (TNs). The aim of this study was to investigate the effects of RTA and to establish whether they were treatment-related by comparison with a matched, untreated control group.The study population included 40 patients with compressive TNs: 22 had nontoxic TNs, and 18 had toxic TNs and were treated with methimazole. In all patients, a fine-needle aspiration cytology was performed to exclude a thyroid malignancy.Twenty patients were treated with RTA (group A), and 20 others did not receive any treatment (group B). At baseline, age, gender, and TN features did not differ significantly between groups. All patients were clinically, biochemically, and morphologically evaluated at baseline and after 1, 3, 6, and 12 months.TN volume significantly decreased in group A (1.8 ± 0.3 ml at 12 months vs. 13.3 ± 1.8 ml at baseline; P < 0.0001) and remained stable in group B [11.7 ± 1.5 ml at 12 months vs. 11.2 ± 1.5 ml at baseline; P = not significant (NS)]. At 3-, 6-, and 12-month evaluations, TN volume was significantly lower in group A than in group B (P < 0.005). At the end of the follow-up, pressure symptoms were improved in all patients in group A but persisted unchanged in group B. In group A, hyperthyroidism completely recovered in 40% and improved in 40% of patients with toxic TNs, whereas it persisted in all patients with toxic TNs in group B. RTA was safe and well tolerated in all patients.RTA induced a marked TN volume shrinkage resulting in parallel improvement of pressure symptoms. In most patients with toxic TNs, hyperthyroidism significantly improved as well. RTA may represent a valid therapeutic approach in patients with TNs not receiving conventional treatments.
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