Role of Metabolic Factors in the Association Between Osteocalcin and Testosterone in Chinese Men

• DOI: 10.1210/jc.2013-1805
• Publication Date: 2013-07-04T08:17:06Z
• Authors: Ming Liao; Xuefeng Guo; Xiaoxiang Yu; Guijian Pang; Shijun Zhang; Jianling Li; Aihua Tan; Yong Gao; Xiaobo Yang; Haiying Zhang; Xue Qin; Linjian Mo; Zheng Lu; Chunlei Wu; Zengnan Mo
• Keywords: Adult; Male; Metabolic Syndrome; 2. Zero hunger; Osteocalcin; Middle Aged; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Asian People; Sex Hormone-Binding Globulin; Linear Models; Humans; Testosterone; Obesity; Aged

Objective: Osteocalcin can regulate energy metabolism and increase testosterone production. Although previous studies have shown the positive association between osteocalcin testosterone, effect of metabolic factors in is unclear. Design Setting: Osteocalcin, were accessed 2400 men aged 20 to 69 years, who participated population-based Fangchenggang Area Male Health Examination Survey Guangxi province China from September 2009 December 2009. Main Outcome Measures: Metabolic syndrome was defined based on updated report National Cholesterol Education Program Adult Treatment Panel III criteria. Serum total osteocalcin, (TT), sex hormone binding globulin (SHBG) measured, whereas free (FT) bioavailable (BT) calculated Vermeulen's formula. The multivariable linear regression analysis used. Results: positively associated with TT, FT, BT unadjusted model (all P < .001). After adjusting for age, TT remained statistically significant (β = .17, 95% confidence interval 0.14–0.20) not attenuated each MetS subgroup including hypertriglyceridemia, hyperglycemia, elevated blood pressure, low high-density lipoprotein cholesterol, while group central obesity (waist circumstance ≥90 cm), appeared significantly stronger 0.21, 0.12–0.30). further SHBG, or any two components .05). Conclusions: which probably modified by SHBG obesity.