Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan

• DOI: 10.1210/jc.2014-1718
• Publication Date: 2014-04-15T15:58:26Z
• Authors: Yu-Li Chen; Shih-Feng Weng; Yuan-Chi Shen; Chien-Wen Chou; Chwen-Yi Yang; Jhi-Joung Wang; Kai-Jen Tien
• Keywords: Adult; Male; 0301 basic medicine; INCREASES; Taiwan; HYPOXIA; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; BONE-RESORPTION; Risk Factors; Humans; Aged; Aged, 80 and over; INVITRO; Sleep Apnea, Obstructive; Incidence; ASSOCIATION; Middle Aged; 3. Good health; MARROW; DISEASES; OBESITY; Case-Control Studies; Osteoporosis; Female; HEALTH; OXYGEN-TENSION

Obstructive sleep apnea (OSA) is associated with metabolic, endocrine, and cardiovascular diseases. It characterized by repetitive episodes of apnea/hypopnea hypoxia in tissues, which might also impact bone metabolism. This study investigates the possible association between OSA osteoporosis.Random samples 1 million individuals were collected from Taiwan's National Health Insurance database. A total 1377 patients newly diagnosed 2000 to 2008 recruited compared a matched cohort 20 655 without OSA. All tracked until an osteoporosis diagnosis, death, or end 2011.During 6-year follow-up period, incidence rates comparison group 2.52 1.00 per 1000 person-years, respectively. Patients found be at 2.74 times risk than (95% confidence interval 1.69-4.44, P < .05), after adjustment for age, gender, diabetes, hypertension, coronary artery disease, obesity, stroke, hyperlipidemia, chronic kidney gout, monthly income, geographical location. Subgroup analysis showed that older female had higher their younger male counterparts. Log-rank revealed significantly cumulative (P .0001).People are increased subsequent osteoporosis.