The Choice of Normative Pediatric Reference Database Changes Spine Bone Mineral Density Z-Scores But Not the Relationship Between Bone Mineral Density and Prevalent Vertebral Fractures

• DOI: 10.1210/jc.2014-3096
• Publication Date: 2014-12-11T13:10:52Z
• Authors: Jinhui Ma; Kerry Siminoski; Nathalie Alos; Jacqueline Halton; Josephine Ho; Brian Lentle; MaryAnn Matzinger; Nazih Shenouda; Stephanie Atkinson; Ronald Barr; David A. Cabral; Robert Couch; Elizabeth A. Cumm...; Conrad V. Fernandez; Ronald M. Grant; Celia Rodd; Anne Marie Sbrocchi; Maya Scharke; Frank Rauch; Leanne M. Ward
• Keywords: Reference database; Standard score

Our objectives were to assess the magnitude of disparity in lumbar spine bone mineral density (LSBMD) Z-scores generated by different reference databases and evaluate whether relationship between LSBMD vertebral fractures (VF) varies choice database. Children with leukemia underwent cross-calibrated dual-energy x-ray absorptiometry, according Hologic Lunar databases. VF assessed Genant method on radiographs. Logistic regression was used association Z-scores. Net reclassification improvement area under receiver operating characteristic curve calculated predictive accuracy for VF. For 186 children from 0 18 years age, 6 age ranges studied. The group highly correlated (r ≥ 0.90), but proportion ≤−2.0 among those varied substantially (from 38–66%). Odds ratios (OR) Z-score similar regardless database (OR = 1.92, 95% confidence interval 1.44, 2.56 OR 2.70, 1.70, 4.28). Area net ranged 0.71 0.75 −0.15 0.07, respectively. Although use a threshold as part definition osteoporosis child does not appear valid, study relationships BMD is valid that used.