Adiponectin, Insulin Sensitivity and Diabetic Retinopathy in Latinos With Type 2 Diabetes

• DOI: 10.1210/jc.2015-1221
• Publication Date: 2015-05-28T17:50:26Z
• Authors: Jane Z. Kuo; Xiuqing Guo; Ronald Klein; Barbara E. Klein; Pauline Genter; Kathryn Roll; Yang Hai; Mark O. Goodarzi; Jerome I. Rotter; Yii-Der Ida Chen; Eli Ipp
• Keywords: Fundus Photography

Insulin resistance and chronic inflammation are key elements in the pathogenesis of type 2 diabetes. We hypothesized that similar mechanisms could have a role development diabetic retinopathy (DR), an important microvascular complication Latinos with diabetes.A cross-sectional, family-based, observational cohort study.Latino subjects diabetes (n = 507), ascertained families via proband known duration 10 years or more and/or DR, were included.Serum adiponectin was measured insulin sensitivity estimated using homeostasis model assessment (HOMA-IR). DR assessed by seven-field digital fundus photography graded modified Airlie House classification Early Treatment Diabetic Retinopathy Scale (range severity levels, 10-85).Fasting concentrations elevated patients compared to those without (12.9 ± 0.5 vs 10.5 μg/mL; P .0004) remained significant after adjusting for multiple covariates (age, gender, body mass index, glycosylated hemoglobin, duration, statin use, blood pressure, renal function; .013 .018). Adiponectin also positively correlated nonproliferative (P < .0003), all covariate adjustments When proliferative group included, this relationship attenuated adjustments, possibly influence glomerular filtration rate reduction group. HOMA-IR not different non-DR groups. Although elevated, retained typical inverse seen group.Serum is diabetes, maintains sensitivity. Adiponectin, whether as marker biological mediator, may play which appears be independent its