Adiponectin Predicts High-Density Lipoprotein Cholesterol Efflux Capacity in Adults Irrespective of Body Mass Index and Fat Distribution

• DOI: 10.1210/jc.2017-00933
• Publication Date: 2017-08-30T14:02:21Z
• Authors: Gunther Marsche; Sieglinde Zelzer; Andreas Meinitzer; Sabine Kern; Sabine Meissl; Gudrun Pregartner; Daniel Weghuber; Gunter Almer; Harald Mangge
• Keywords: High-density lipoprotein

Obesity is associated with hypoadiponectemia, dyslipidemia, and increased risk of cardiovascular disease (CVD). Mechanisms linking these conditions remain to be fully understood. Cholesterol efflux capacity (CEC) a crucial functional property high-density lipoprotein (HDL) that strongly predicts CVD incidence. We investigated whether age, fat distribution, other obesity-related factors affect CEC in juvenile adult overweight/obese participants the STYJOBS/EDECTA cohort (NCT00482924). performed an observational study. its association body measures related metabolic parameters was assessed 683 (281 juveniles, whom 227 were overweight/obese; 402 adults, 197 overweight/obese). Pearson correlation analysis showed that, after Bonferroni correction, significantly inversely correlated mass index (BMI), carotid diameter, waist circumference, waist-to-hip, waist-to-height ratio, oxidized low-density lipoprotein, uric acid liver markers alanine-aminotransferase choline esterase. positively HDL cholesterol, total apolipoprotein A1, adiponectin whereas juveniles only A1 significant positive CEC. Age-stratified linear regression analyses as outcome variable identified most predictor adults. The results did not change when either BMI or waist-to-hip ratio factor distribution included models. Hypoadiponectemia robust reduced cholesterol adults irrespective distribution. Further investigations are needed assess causal determinant