Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects

• DOI: 10.1210/jc.2017-01397
• Publication Date: 2017-08-04T18:09:02Z
• Authors: Vanessa Legry; Sven Francque; Joel T Haas; An Verrijken; Sandrine Caron; Oscar Chávez-Tala...; Emmanuelle Vallez; Luisa Vonghia; Eveline Dirinck; Ann Verhaegen; Mostafa Kouach; Sophie Lestavel; Philippe Lefebvre; Luc Van Gaal; Anne Tailleux; Réjane Paumelle; Bart Staels
• Keywords: Homeostasis; Homeostatic model assessment; FGF21

Bile acids (BAs) are signaling molecules controlling energy homeostasis that can be both toxic and protective for the liver. BA alterations have been reported in obesity, insulin resistance (IR), nonalcoholic steatohepatitis (NASH). However, whether contribute to NASH independently of metabolic status is unclear. To assess associated with body mass index IR. Patients visiting obesity clinic Antwerp University Hospital (a tertiary referral facility) were recruited from 2006 2014. Obese patients biopsy-proven (n = 32) healthy livers 26) matched on model assessment Transcriptomic analyses performed liver biopsies. Plasma concentrations 21 species 7α-hydroxy-4-cholesten-3-one, a marker synthesis, determined by liquid chromatography–tandem spectrometry. fibroblast growth factor 19 was measured enzyme-linked immunosorbent assay. did not correlate any hepatic lesions, whereas, as previously reported, primary strongly correlated showed unaltered metabolism patients. In line, plasma 7α-hydroxy-4-cholesten-3-one unchanged NASH. Moreover, no sign accumulation or activation receptors—farnesoid X, pregnane vitamin D receptors—was found. Finally, 19, secondary-to-primary BA, free-to-conjugated ratios similar, suggesting intestinal signaling. obese patients, related phenotype NASH, especially IR, but necroinflammation.