Persistence of Excess Mortality Following Individual Nonhip Fractures: A Relative Survival Analysis

• DOI: 10.1210/jc.2017-02656
• Publication Date: 2018-05-17T00:28:45Z
• Authors: Thach Tran; Dana Bliuc; Louise Hansen; Bo Abrahamsen; Joop van den Bergh; John A Eisman; Tineke van Geel; Piet Geusens; Peter Vestergaard; Tuan V Nguyen; Jacqueline R Center
• Keywords: Excess mortality; Hip Fracture; Absolute risk reduction; Risk of mortality

Little is known about long-term excess mortality following fragility nonhip fractures. The study aimed to determine which fracture was associated with and for how long the postfracture persisted. This nationwide registry-based follow-up included all individuals in Denmark aged 50+ years who first experienced fractures 2001 were followed up 10 their risk. contribution of at precise time intervals examined using relative survival analysis, accounting time-related changes background population. There 21,123 women (aged 72 ± 13 years) 9481 men 67 12 an incident 2001, by 10,668 4745 deaths, respectively. Excess observed proximal lower leg majority deaths occurred within year after fracture, thereafter gradually declined. Hip highest (33% 20% 1 women, respectively). One-year a femur or pelvis 25%; vertebrae, 10%; humerus, rib, clavicle, 5% leg, 3%. A significant although smaller still until hip ~5 femur, other proximal, highlights important wide variety thus potential benefit from early intervention.