Patterns of Cardiometabolic Health as Midlife Women Transition to Menopause: A Prospective Multiethnic Study

• DOI: 10.1210/jc.2018-00941
• Publication Date: 2018-10-25T22:18:51Z
• Authors: Elizabeth Ward; Ellen B Gold; Wesley O Johnson; Feihong Ding; Po-Yin Chang; Paula Song; Samar R El Khoudary; Carrie Karvonen-G...; Kelly R Ylitalo; Jennifer S Lee
• Keywords: Abdominal obesity

Cardiometabolic conditions increase in midlife, but early customized prevention strategies are not established for such women. To characterize and identify factors longitudinally related to constellations of cardiometabolic risk components multiracial/ethnic women midlife. We conducted a prospective, longitudinal, multiethnic cohort study 3003 midlife undergoing menopausal transition (MT). Metabolic syndrome (MetS) was defined as having at least three five components: high fasting triglyceride (hTG) level, low high-density lipoprotein cholesterol (lHDL-C) plasma glucose (hGluc) large waist circumference (abdominal obesity; Ob), hypertension (HTN). described the patterns estimated hazard ratios (HRs) (i) incident MetS (ii) recovery from MetS, using multivariable-adjusted Cox regression. Seven US sites. In all, 1412 non-Hispanic white, 851 black, 272 Japanese, 237 Hispanic, 231 Chinese Race/ethnicity, lifestyle factors, MT stage. constellations, recovery. Central obesity most frequent component. Having no (31%) baseline constellation. Physical activity (HR = 1.68; 95% CI: 1.06, 2.68) lower caloric intake 0.96; 0.93, 0.99 per 100 cal/d) were associated with MetS. Ob/hTG/lHDL-C (18%), Ob/HTN/lHDL-C (16%), Ob/HTN/hGluc (14%) constellations. Physically active had 26% 62% hazards than inactive Modifiable behaviors decreased