Defect of Villous Cytotrophoblast Differentiation into Syncytiotrophoblast in Down's Syndrome

• DOI: 10.1210/jc.85.10.3700
• Publication Date: 2004-02-25T21:56:42Z
• Authors: J. L. Frendo
• Keywords: Cytotrophoblast; Syncytiotrophoblasts

The syncytiotrophoblast (ST) is one of the major components human placenta as it involved in feto-maternal exchanges and secretion pregnancy-specific hormones.The aim this study was to elucidate formation function ST trisomy 21 (Down syndrome).We first used vitro model cytotrophoblast differentiation into ST.Cytotrophoblasts were isolated from 15 21-affected placentas (12-35 weeks gestation) 10 gestational age-matched control placentas.In cytotrophoblasts normal fused form ST.This associated with an increase transcript levels chorionic gonadotropin (hCG), placental lactogen (hPL), growth hormone (PGH) leptin.In placentas, we observed a defect (or delay) dramatic decrease synthesis these hormones compared cultured cells placentas.These results confirmed by significant (p<0.001)decrease gene expression total homogenates control.These will be help understanding maternal hormonal markers fetal consequences defects for development.