Augmented Placental Production of Leptin in Preeclampsia: Possible Involvement of Placental Hypoxia1

• DOI: 10.1210/jcem.83.9.5117
• Publication Date: 2014-01-08T12:03:29Z
• Authors: Hiroko Mise; Norimasa Sagawa; Tsunekazu Matsumoto; Shigeo Yura; Hidetaka Nanno; Hiroaki Itoh; Takahide Mori; Hiroaki Masuzaki; Kiminori Hosoda; Yoshihiro Ogawa; Kazuwa Nakao
• Keywords: Hypoxia

Preeclampsia (PE) is a hypertensive disorder, which develops in late pregnancy and usually associated with placental hypoxia dysfunction. We have recently demonstrated that leptin novel placenta-derived hormone humans suggested its significance human (see Ref. 19). To explore the changes production placenta PE, we measured plasma level messenger RNA expression pregnant women PE. Plasma levels preeclamptic were elevated significantly, compared gestational age- body mass index-matched normal (P < 0.0001). severe PE group significantly higher than those mild reduced, soon after delivery, to expected for their indices. Northern blot analysis revealed are increased placentas from women, women. Leptin secretion was trophoblastic cell line (BeWo cells) cultured under hypoxic conditions (5% O2), standard (20% O2; P 0.01). The present study of augmented probably because hypoxia, thereby suggesting possible as marker