Interleukin-8 in the Human Fallopian Tube

0301 basic medicine Staining and Labeling Macrophages Interleukin-8 CD13 Antigens Immunohistochemistry Receptors, Interleukin-8B Receptors, Interleukin-8A 3. Good health 03 medical and health sciences 0302 clinical medicine Humans Female Tissue Distribution Fallopian Tubes
DOI: 10.1210/jcem.86.6.7584 Publication Date: 2014-01-08T17:06:53Z
ABSTRACT
The human fallopian tube is a dynamic structure that undergoes cyclic variation in its functional epithelium. This epithelium contains both secretory and ciliated cells. The mechanisms regulating the growth and function of the tubal epithelium are not fully understood. Interleukin-8 (IL-8) is one potential local regulatory factor. We therefore characterized the IL-8 system, which includes IL-8, its receptors A and B, and its degradative enzyme aminopeptidase N, in the human fallopian tube by immunohistochemistry. Immunohistochemistry was performed on isthmic, ampullary, and fimbrial fallopian tubal segments obtained from women undergoing gynecological surgical procedures for benign conditions (n = 52). IL-8 was found in the human fallopian tube predominantly in the epithelial cells. It was present in greater amounts in the distal compared with the proximal tube. IL-8 receptors A and B localized in the tube in similar patterns. The degradative enzyme aminopeptidase N is found in tubal stromal tissue at the epithelial stromal border and perivascularly and may limit the systemic effects of epithelial IL-8. The IL-8 system seems to be an active component of tubal physiology.
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