Expression of Inflammatory Cytokines in Placentas from Women with Preeclampsia1

• DOI: 10.1210/jcem.86.6.7585
• Publication Date: 2014-01-08T17:06:53Z
• Authors: Deborah Fairchild...; Alexander Smarason; Christopher W. G....; Cynthia Sims; Kirk P. Conrad
• Keywords: Alpha (finance); Hypoxia

It is postulated that inadequate remodeling of the uterine spiral arteries in preeclampsia leads to focal ischemia and generation inflammatory cytokines, such as tumor necrosis factor (TNFα) interleukins (ILs), by placenta. Our objective was compare TNFα, IL-1α, IL-1β, IL-6 levels placentas from patients with normal term pregnancies. Because placenta a large heterogeneous organ, we analyzed multiple sites per On average, there 3-fold variation cytokine protein across eight for each However, were no significant overall differences among term, preeclamptic, preterm women without preeclampsia. There also TNFα messenger ribonucleic acid between preeclamptic placentas, although lower diagnosis than placentas. In vitro, hypoxia stimulated production IL-1α but not IL-6, placental villous explants both groups patients, this exaggerated Finally, peripheral venous elevated compared ratio significantly different 1.0 either patient group. Taken together, these results suggest sources other contribute concentrations found circulation women.