12434 History Of Surgical Menopause Is Associated With An Accelerated “Adrenal Aging” In Menopausal Women

• DOI: 10.1210/jendso/bvae163.1608
• Publication Date: 2024-10-05T21:15:20Z
• Authors: Jasmine Saini; Rohit Nathani; Joseph Larson; Vanessa Fell; Irina Bancos
• Keywords: Surgical Menopause

Abstract Disclosure: J. Saini: None. R. Nathani: Larson: V. Fell: I. Bancos: Background: Surgical menopause due to bilateral salpingo-oophorectomy (BSO) at a younger age is associated with an increased risk of cardiovascular disease, cognitive decline, and mortality. Aging abnormalities in steroid metabolome, most notably glucocorticoid androgen ratio (“adrenal aging”). We hypothesized that postmenopausal women the same age, duration adrenal aging. Objective: To determine differences metabolome history BSO as compared age-matched following natural menopause. Methods: conducted single-center cross-sectional study or without BSO, between December 2020 2022 Each participant collected 24-hour urine, which was analyzed for profiling by liquid chromatography-tandem mass spectrometry (25 steroids). Exclusion criteria were inability collect 24h urine sample, exogenous use, advanced malignancy, chronic opioid use. Primary endpoints glucocorticoid/androgen ratio, 11β-hydroxysteroid dehydrogenase type 2 activity (cortisol/cortisone, Tetrahydrocortisol (THF) + 5 α-tetrahydrocortisol (5 α-THF)/ Tetrahydrocortisone, THE) α-reductase (Tetrahydrocortisol (THF)/5 α-THF) Etiocholanolone/Androsterone, Et/An). Results: A total 245 enrolled: 124 (median 66 years, IQR 63-72) 121 68 64-71) who underwent (P=0.214). Median 44 years (IQR 41-46) group, 50 48-53) group. History hormone replacement therapy estrogen reported 161 (66%) women, more frequently (92% vs 39%, P<0.001) longer 12 6-16) 6 3-9), Although both groups had similar levels urinary androgens 1387 1686 mcg/24h, P=0.063) glucocorticoids 10877 10277 P=0.354), demonstrated higher 7.9 5.0-11.1) 6.7 (4.3-9.9), P=0.014), lower Et/An 1.4 1.6, P=0.045), but not THF/5aTHF 1.7 1.8, P=0.380) comparison No found other ratios. Conclusion: Women undergoing menopause, suggestive BSO-induced accelerated “adrenal aging”. Future studies need examine associations abnormal morbidity, frailty, mortality BSO. Presentation: 6/3/2024