Vitamin D Supplementation in Patients With Type 2 Diabetes: The Vitamin D for Established Type 2 Diabetes (DDM2) Study

• DOI: 10.1210/js.2018-00015
• Publication Date: 2018-02-26T15:31:00Z
• Authors: Edith Angellotti; David D’Alessio; Bess Dawson-Hughes; Jason Nelson; Robert M Cohen; Amalia Gastaldelli; Anastassios G Pittas
• Keywords: Clinical Research Article; 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Observational data support a role for vitamin D in type 2 diabetes, but evidence from trials is inconclusive.To evaluate the effect of supplementation on β-cell function and hemoglobin A1c (HbA1c) patients with well-controlled diabetes.Double-blind, randomized, placebo-controlled clinical trial.Tufts Medical Center, Boston, MA; VA Cincinnati, OH.A total 127 (mean age, 60 years) stable (HbA1c ≤7.5%) diabetes managed lifestyle only or plus metformin.Subjects were given 4000 units D3 (cholecalciferol) daily placebo 48 weeks.Insulin secretion rate (ISR) was estimated peripheral plasma C-peptide levels after 3-hour 75-g oral glucose tolerance test done at baseline week 24. Changes HbA1c assessed 16, 24, 36, weeks.Baseline mean 25-hydroxyvitamin [25(OH)D] concentration 26.6 ng/mL, 6.6%, 78% metformin. At 25(OH)D changed by 20.5 -1.6 ng/mL groups, respectively (P < 0.001). The groups did not differ change ISR HbA1c. Among treated (n = 28), reduced compared (-0.1% vs 0.3%, respectively; P 0.034) This result observed other time points could be due to chance.Vitamin IU/d metformin selected deficiency.