Cortical lesions in primary progressive multiple sclerosis

• DOI: 10.1212/wnl.0b013e3181a0fee5
• Publication Date: 2009-04-13T20:43:49Z
• Authors: M. Calabrese; M. A. Rocca; M. Atzori; I. Mattisi; V. Bernardi; A. Favaretto; L. Barachino; C. Romualdi; L. Rinaldi; P. Perini; P. Gallo; M. Filippi
• Keywords: Adult; Cerebral Cortex; Male; Adolescent; Middle Aged; Multiple Sclerosis, Chronic Progressive; Magnetic Resonance Imaging; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Multivariate Analysis; Disease Progression; Image Processing, Computer-Assisted; Humans; Female; Longitudinal Studies; 10. No inequality

<b>Background:</b> In primary progressive multiple sclerosis (PPMS), a discrepancy exists between the modest brain white matter (WM) lesion burden and severity of neurologic disability. Double-inversion recovery (DIR) sequences have improved MRI sensitivity in detection cortical lesions (CLs) patients with relapsing-onset MS. <b>Objective:</b> This 2-year longitudinal study was designed to assess frequency, extent, rate formation CLs PPMS their relationship T2 volume (LV), gray (GM) atrophy, <b>Methods:</b> Forty-eight underwent clinical magnetic resonance examinations at baseline after 2 years. The number CLs, WM LV, GM fraction (GMf) were assessed follow-up. <b>Results:</b> At baseline, detected 81.2% PPMS. least one new CL found 28 during PPMS, LVs increased over volumes significantly correlated GMf, disease duration, Expanded Disability Status Scale score, as well increasing atrophy disability A multivariate analysis showed that an independent predictor percentage change accumulation subsequent period. <b>Conclusions:</b> Cortical are frequent finding sclerosis. extent such abnormalities is associated disability, able predict changes medium time