Spectrum of paraneoplastic disease associated with lymphoma

• DOI: 10.1212/wnl.0b013e31820d62eb
• Publication Date: 2011-02-22T02:12:59Z
• Authors: C. Briani; R. Vitaliani; W. Grisold; J. Honnorat; F. Graus; J.C. Antoine; G. Bertolini; B. Giometto
• Keywords: Paraneoplastic cerebellar degeneration; Peripheral Nervous System; Cerebellar Degeneration

To define the frequency and clinical immunologic characteristics of patients affected by paraneoplastic neurologic syndromes (PNS) lymphoma.Patients fulfilling criteria for PNS associated with lymphoma collected from European Commission-funded Euronetwork group database were analyzed.Fifty-three Hodgkin (HL) (24 patients, mean age 51, range 16-84) or non-Hodgkin (NHL) (29 64, 31-82) analyzed. The most commonly was cerebellar degeneration, present in 21 cases, a higher prevalence HL (16/24 cases). Peripheral nervous system (mainly demyelinating polyradiculopathies) motor neuron involvement more common NHL. Onconeural antibodies frequent against Tr antigen. Fifty percent responded to chemotherapy, whereas improvement less (24%) In both groups, survival rate good. Overall, 10 out 53 eventually died, only 2 (1 HL, 1 NHL) dying PNS.PNS are relatively rare. Paraneoplastic mainly anti-Tr antibodies, is prevalent NHL, followed our study disease Involvement peripheral heterogeneous, polyradiculoneuritis