Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort

• DOI: 10.1212/wnl.0b013e31823ed0f0
• Publication Date: 2011-12-15T06:23:33Z
• Authors: N.S.M. Schoonenboom; F.E. Reesink; N.A. Verwey; M.I. Kester; C.E. Teunissen; P.M. van de Ven; Y.A.L. Pijnenburg; M.A. Blankenstein; A.J. Rozemuller; P. Scheltens; W.M. van der Flier
• Keywords: Memory clinic; Memory problems

To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated (p-tau) levels in CSF behave a large cohort of patients with different types dementia.Baseline was collected from 512 Alzheimer disease (AD) 272 other dementia (OD), 135 psychiatric disorder (PSY), 275 subjective memory complaints (SMC). Aβ42, t-tau, p-tau (at amino acid 181) were measured by ELISA. Autopsy obtained subgroup 17 patients.A correct classification AD (92%) OD (66%) accomplished when Aβ42 combined. Patients progressive supranuclear palsy had normal biomarker values 90%. Creutzfeldt-Jakob demonstrated an extremely high t-tau at relatively p-tau. profile seen 47% Lewy bodies (DLB), 38% corticobasal degeneration (CBD), almost 30% frontotemporal lobar (FTLD) vascular (VaD). PSY SMC biomarkers 91% 88%. Older are more likely to have profile. Concordance between clinical neuropathologic diagnosis 85%. markers reflected neuropathology 94%.CSF useful differential diagnosis. However, DLB, FTLD, VaD, CBD, substantial group exhibit profile, which requires autopsy confirmation the future.