Central nervous system involvement in dengue

• DOI: 10.1212/wnl.0b013e31824b94e9
• Publication Date: 2012-02-23T07:04:43Z
• Authors: F.M.C. Araújo; M.S. Araújo; R.M.R. Nogueira; R.S.N. Brilhante; D.N. Oliveira; M.F.G. Rocha; R.A. Cordeiro; R.M.C. Araújo; J.J.C. Sidrim
• Keywords: Adult; Aged, 80 and over; Male; Adolescent; Infant; Dengue Virus; Middle Aged; 3. Good health; Dengue; 03 medical and health sciences; 0302 clinical medicine; Meningoencephalitis; Child, Preschool; Central Nervous System Viral Diseases; Humans; Female; Encephalitis, Viral; Child; Aged

<h3>Objective:</h3> This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. <h3>Methods:</h3> Samples 150 suspect an disease and outcomes were investigated for evidence presence DENV. The sampling was made up CSF, 120 tissue samples, 109 blood specimens. tests used viral isolation, reverse transcriptase PCR, immunohistochemistry, nonstructural 1 antigen, immunoglobulin M detection. <h3>Results:</h3> Out studied patients, 84 positive. Evidence DENV found 41 showing following neurologic diagnosis: 46.3% encephalitis, 34.1% meningoencephalitis, 19.5% meningitis, giving a 48.8% dengue-positive cases. major clinical manifestations observed on these fever, headache, mental irritability, breathless, vomiting, muscle pain, tiredness, abdominal somnolence, restlessness, dizziness, cough, seizure, coma, neck stiffness. <h3>Conclusion:</h3> Clinical laboratory-positive results CSF that may indicate led consider invasion cases studied, showed pathology important complication