Primary progressive aphasia

• DOI: 10.1212/wnl.0b013e3182574f79
• Publication Date: 2012-05-10T05:54:22Z
• Authors: S.A. Sajjadi; K. Patterson; R.J. Arnold; P.C. Watson; P.J. Nestor
• Keywords: Primary progressive aphasia

Primary progressive aphasia (PPA) has been proposed to comprise 3 discrete clinical subtypes: semantic, agrammatic/nonfluent, and logopenic. Recent consensus recommendations suggest a diagnostic framework based primarily on neuropsychological findings classify these variants. Our objective was evaluate the extent which patients with PPA would conform tripartite system whether clustering pattern of elements linguistic profile suggests syndromes.A total 46 were prospectively recruited Cambridge Longitudinal Study PPA. Sufficient data collected assess all consensus-proposed domains. By comparing patients' performances against those 30 age- education-matched healthy volunteers, z scores calculated, values 1.5 SDs outside control participants' means considered abnormal. Raw test used undertake principal factor analysis identify individual measures.Of patients, 28.3%, 26.1%, 4.3% fitted nonfluent/agrammatic, logopenic categories respectively, 41.3% did not fulfill for any There no significant between-group difference in age, education, or disease duration. Furthermore, outcome keeping semantic nonfluent/agrammatic syndromes but support variant.Taken together, results this prospective data-driven study that although substantial proportion have neither nor nonfluent variants, they do necessarily variant.