Clinical presentation of chronic traumatic encephalopathy

• DOI: 10.1212/wnl.0b013e3182a55f7f
• Publication Date: 2013-08-22T01:47:38Z
• Authors: Robert A. Stern; Daniel H. Daneshvar; Christine M. Baugh; Daniel R. Seichepine; Philip H. Montenigro; David O. Riley; Nathan G. Fritts; Julie M. Stamm; Clifford A. Robbins; Lisa McHale; Irene Simkin; Thor D. Stein; Victor E. Alvarez; Lee E. Goldstein; Andrew E. Budson; Neil W. Kowall; Christopher J. No...; Robert C. Cantu; Ann C. McKee
• Keywords: Chronic traumatic encephalopathy

The goal of this study was to examine the clinical presentation chronic traumatic encephalopathy (CTE) in neuropathologically confirmed cases.Thirty-six adult male subjects were selected from all cases CTE at Boston University Center for Study Traumatic Encephalopathy brain bank. Subjects athletes, had no comorbid neurodegenerative or motor neuron disease, and next-of-kin informants provide retrospective reports subjects' histories presentations. These interviews conducted blind neuropathologic findings.A triad cognitive, behavioral, mood impairments common overall, with cognitive deficits reported almost subjects. Three asymptomatic time death. Consistent earlier case boxers, 2 relatively distinct presentations emerged, one group whose initial features developed a younger age involved behavioral and/or disturbance (n = 22), another an older impairment 11).This suggests there are major CTE, behavior/mood variant other variant.