Spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in Senegalese baboons ( Papio papio )

• DOI: 10.1212/wnl.26.3.273
• Publication Date: 2012-05-13T12:00:58Z
• Authors: JUHN A. WADA; TAKESHI OSAWA
• Keywords: Male; Time Factors; Electroencephalography; Amygdala; Electric Stimulation; Functional Laterality; Disease Models, Animal; 03 medical and health sciences; 0302 clinical medicine; Recurrence; Seizures; Animals; Humans; Female; Epilepsies, Partial; Papio

Daily electrical stimulation of the amygdala in Senegalese baboons (Papio papio) resulted in the development of generalized convulsive seizures focal onset through five distinct clinical stages in an average of 72 days. The chronologic pattern of electroclinical features suggested that vertical intrahemispheric ictal dissemination was of primary importance in the progressive seizure development. Some animals developed spontaneous recurrence of both partial complex and primary generalized seizures. The kindling preparation in P. papio represents a unique model of human epilepsy with its secondary generalized convulsive seizure development, spontaneously recurrent partial and primary generalized seizures in the background of predisposed epileptogenic susceptibility.