Secondarily generalized convulsive seizures induced by daily amygdaloid stimulation in rhesus monkeys

• DOI: 10.1212/wnl.28.10.1026
• Publication Date: 2012-05-13T12:07:02Z
• Authors: J. A. Wada; T. Mizoguchi; T. Osawa
• Keywords: Pure autonomic failure; Etiology

Amygdaloid kindling in rhesus monkeys resulted development of secondarily generalized convulsive seizures an average 196 days. Prior pharmacologic (bemegride) accelerated this seizure one animal. None the animals reached stage 5 primary baboons (Papio papio), even after 400 daily amygdaloid stimulations. Seizure instability, with frequent regression to earlier stage, and difficulty establishing a triggering threshold most monkeys, contrasts our experiences Papio papio. Thus, differences speed quality kindled convulsion between epileptic probably reflect presence or absence epileptogenic predisposition these two species. The developing suggests that species is particularly suited for study partial complex seizure. These studies indicate abrupt onset human epilepsy fully developed must represent overwhelming central pathophysiologic event resulting from endogenous, exogenous combined insult interacting genetically predisposed susceptibility.