Loss of serotonin‐containing neurons in the raphe of patients with myotonic dystrophy

• DOI: 10.1212/wnl.50.2.535
• Publication Date: 2012-05-13T13:31:53Z
• Authors: S. Ono; K. Takahashi; K. Jinnai; F. Kanda; Y. Fukuoka; H. Kurisaki; S. Mitake; T. Inagaki; T. Yamano; K. Nagao
• Keywords: Raphe; Serotonergic cell groups; Dystrophy

Hypersomnia occurs frequently in patients with myotonic dystrophy (MyD). We performed a quantitative immunohistochemical study of serotonin (5—HT) containing neurons linked to hypersomnia the dorsal raphe nucleus (DRN) and superior central (SCN) 8 MyD, 5 whom showed hypersomnia, 12 age-matched controls. The densities 5—HT DRN SCN were significantly lower MyD than without These data suggest that loss is associated presence MyD.