Significance of interictal temporal lobe delta activity for localization of the primary epileptogenic region

• DOI: 10.1212/wnl.52.1.202
• Publication Date: 2012-05-13T13:37:56Z
• Authors: J.D. Geyer; E. Bilir; R.E. Faught; R. Kuzniecky; F. Gilliam
• Keywords: Adult; Male; Adolescent; Middle Aged; Temporal Lobe; 03 medical and health sciences; 0302 clinical medicine; Delta Rhythm; Epilepsy, Temporal Lobe; Humans; Female; Child

Because interictal temporal lobe delta activity (TLDA) has been described in 30 to 90% of patients with epilepsy (TLE) but not investigated extratemporal epilepsy, we sought determine the localizing significance TLDA. We compared presurgical scalp EEG results 47 consecutive who received resection (40 frontal and 7 parietal-occipital) for intractable 43 anterior lobectomy. defined lateralized TLDA as runs lower than 4-Hz waveforms that were easily distinguished from background rhythms maximal at electrodes T4, F8, T6 or T3, F7, T5. The was subcategorized intermittent rhythmic (TIRDA) polymorphic (TIPDA). A chi-square test used association epileptogenic zone TIRDA TIPDA. found 12 (28%) TIPDA 8 (19%) group, 2 (4%) 9 group. strongly associated TLE (p < 0.003), whereas occurred an equal rate both groups. Similar is present up 20% epilepsy. presence suggests may infrequently occur Caution should be when using a finding.