Accumulation of microtubule-based motor protein in a patient with colchicine myopathy

• DOI: 10.1212/wnl.55.9.1414
• Publication Date: 2012-05-13T13:49:29Z
• Authors: A. Shinde; S. Nakano; M. Abe; N. Kohara; I. Akiguchi; H. Shibasaki
• Keywords: Colchicine

Colchicine has been used therapeutically for gout more than 200 years. Recently, the drug also autoimmune diseases such as Behcet disease. However, long-term use of colchicine can cause vacuolar myopathy.1,2⇓ Concomitant cyclosporin or renal insufficiency exaggerates toxic effect colchicine.1,2⇓ myopathy sometimes occurs in organ transplant recipients, although it may be unrecognized.3 inhibits polymerization microtubules by interacting with tubulin, a monomeric component microtubules. As particles and membranous organelles including lysosomes autophagic vacuoles are conveyed along microtubule-dependent cytoskeletal network,4 disruption this network result intracellular accumulation vacuoles.2

We report patient disease who had treated cyclosporin. The showed subacute proximal myopathy, his muscle biopsy findings were compatible myopathy. To confirm pathogenesis we immunolocalized dynein, driving force microtubules.5,6⇓

A 60-year-old man …